Status of Sialic Acid in Patients with Cervical Intraepithelial Neoplasia and Cervical Carcinoma
نویسنده
چکیده
Cervical cancer, a malignant disease that invades the uterine cervix, is preceded by a long phase of precursor lesion known as cervical intraepithelial neoplasia. (CIN). The present study investigated the clinical utility of total sialic acid and lipid-bound sialic acid (LSA) levels in CIN and cervical cancer. The present study also investigated histochemical expression of glycoproteins in cervical tissue. Serum levels of TSA and LSA were measured in patients with lowgrade squamous intraepithelial lesion (LSIL), high-grade squamous intraepithelial lesion (HSIL), and stage I, II and III cervical cancer and age matched controls. The levels of serum TSA were significantly altered in CIN patients and cervical cancer patients with stage I, II and III. Histochemical analysis showed high expression of glycoproteins in cervical cancer as compared to patients with CIN and healthy subjects. Measurement of both TSA and LSA in cervical cancer patients could be used as an adjunct to diagnosis, monitor response to therapy and assess the staging of cancer.
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